Born on April 8, 1923 in rural White County, Arkansas, George Fisher was one of the most famous and renowned political cartoonists in Arkansas history. His work, which carried a strongly liberal and progressive tone, could be found in several Arkansas news publications, most notably the North Little Rock Times, the Arkansas Gazette, and the Arkansas Times.

Fisher had an interest in drawing and cartooning from his childhood onward, and began studies at what is now Arkansas State University-Beebe before being called to fight in World War Two. While in Europe Fisher continued to hone his talents, drawing for the regimental newspaper and attending art classes at the Municipal College of Art in Bournemouth, England. While in Bournemouth, Fisher met Rosemary Beryl Snook, who he would marry after the war in 1946.

Upon finishing his degree, Fisher started his career as a political cartoonist working for the West Memphis-based Arkansas News. The Arkansas News was a reformist newspaper that opposed the political machine in Crittenden County. When the paper folded, Fisher moved to Little Rock and established a commercial art service which continued for the rest of his life.

While in Little Rock, George Fisher continued to be involved in political art, producing advertisements for the gubernatorial campaigns of Sidney S. McMath and the 1954 gubernatorial campaign of Orval Faubus. Fisher also volunteered his cartooning skills for the North Little Rock Times and soon saw his cartoons be republished by the Pine Bluff Commercial and the Sunday Arkansas Gazette. Fisher became the Gazette's full-time Cartoonist in 1976; a position he held until the paper's 1991 closing. After that, Fisher took a position as the cartoonist of the Arkansas Times, a weekly news magazine.

As a cartoonist, George Fisher had several favorite themes and targets, including Orval Faubus and his supporters. Fisher helped popularize the Farkleberry by making reference to an incident in which Faubus was describing the brush to state highway workers. Fisher also originally created the "Old Guard Rest Home" as a holding area for Faubus and his prominent followers as they left office before expanding membership to include other defeated conservative Arkansas politicians. Fisher was also a staunch environmentalist and frequently lampooned the U.S. Army Corps of Engineers and their frequent construction projects in Arkansas.

In addition to his cartoon work, George Fisher also created a puppet show called Phydeaux and His Friends with his wife in the 1950s and they were also a major driving force behind the Rackensack folk music collective in Arkansas. Fisher also commemorated his wife, who died in 1983, by hiding her nickname of "Snooky" in his cartoons. George Fisher died on December 15, 2003 at his home in Little Rock.